CYCLIN D1
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What is this Test About?
Cyclin-D1 is one of the members of cell cycle proteins that drives the transition between G0 & G1 phase. In normal tissues, basal epithelial cells, endothelial cells & stromal cells are often Cyclin-D1 positive. Due to translocation involving Cyclin-D1 gene & IgH, majority of Mantle cell Lymphomas overexpress Cyclin-D1. This is a useful feature in the classification of Low grade B cell lymphomas.
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