E CADHERIN
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What is this Test About?
E-Cadherin (ECAD) is typically associated with epithelial differentiation. It is immunoreactive in epithelial neoplasms as well as mesenchymal tumors with epithelial characteristics like Synovial sarcoma. Strong E-cadherin membranous staining is used to define Ductal carcinomas of breast & differentiate from Lobular carcinomas which are negative. Loss of cell surface E-Cadherin expression is also seen in Solid pseudopapillary neoplasms of the pancreas.
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