FANCONI'S ANEMIA, STRESS CYTOGENETICS

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What is this Test About?
Chromosomes from a patient with a congenital form of bone marrow failure, Fanconi's anemia (FA), are sensitive to clastogenic agents (chemicals causing DNA breakage) like Mitomycin C (MMC). The effect of MMC on lymphocytes in culture is used to differentiate reliably between FA patients with chromosome instability and Idiopathic aplastic anemia.
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