FISH : HER2
[Erbb2] Amplification

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What is this Test About?
Amplification or overexpression of Human epidermal growth factor receptor 2 gene (ERBB2) is seen in 15-20% of patients with breast cancer and is associated with shortened disease free & overall survival. Since targeted therapies are available to effectively treat Her2 positive breast cancer, accurate assessment of Her2 status is critically important in the selection of correct therapy such as Trastuzumab (Herceptin) / Pertuzumab. FISH technique is specially useful in Her2 equivocal tumors. As per ASCO 2018 guidelines, all newly diagnosed patients with breast cancer who develop metastatic disease should undergo Her2 test on tissue from metastatic site.
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