FISH FOR del(7q)

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What is this Test About?
Monosomy 7 or del(7q) is the most common somatic cytogenetic abnormality in persons with Secondary MDS/AML who were previously diagnosed with an acquired bone marrow failure. This aberration occurs in 8% of de novo Acute Myeloid Leukemia (AML), in 5-10% of de novo patients with Myelodysplastic syndrome (MDS), and approximately 50% of therapy-related Myeloid neoplasms. Myeloid malignancies with monosomy 7 or del(7q) respond poorly to chemotherapy and are associated with an unfavorable prognosis.
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