FISH FOR PML/RARA DETECTION

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What is this Test About?
Acute Promyelocytic Leukemia (APL) in its typical presentation expresses PML-RARA rearrangement due to translocation t(15;17), as seen in 95% of patients. These patients have good clinical outcome on treatment with differentiation therapy comprising of all-trans retinoic acid ATRA & ATO. Early diagnosis & immediate treatment of APL is essential as it is a medical emergency which may lead to complications such as intra-vascular coagulation & cerebral haemorrhage.
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