IGG4
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What is this Test About?
IgG4-related disease is a recently recognized syndrome of unknown etiology most often occurring in middle-aged and older men. Several organ systems can be involved and encompasses many previous and newly described diseases such as Type1 autoimmune pancreatitis; Mikulicz disease and Sclerosing sialadenitis; Inflammatory orbital pseudotumor; Chronic sclerosing aortitis; Riedel thyroiditis, a subset of Hashimoto thyroiditis; IgG4-related interstitial pneumonitis; and IgG4-related tubulointerstitial nephritis. Each of these entities is characterized by tumor-like swelling of the involved organs with infiltrative, predominately IgG4-positive plasma cells with accompanying "storiform" fibrosis.
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