KRAS & NRAS MUTATION ANALYSIS PANEL

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What is this Test About?
RAS mutations are commonly found in cancer tissue, causing a permanent activation of the signal transduction pathway downstream of the EGF receptor (EGFR), thus positive signaling for cell growth. Most frequent are KRAS mutations in codons 12,13 in the second (first transcribed) exon. Up to 45% of all colorectal cancer patients exhibit KRAS 12,13 mutations, while another 10-15% may have mutations in KRAS exons 3 and 4 or in the respective regions of the homologous NRAS gene.
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