P16 INK4A
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What is this Test About?
p16 expression plays a major role in the evaluation of Cervical Squamous Intraepithelial lesions (SIL) & distinguishing dysplasia from benign mimics. Overexpression is seen in most high risk HPV associated squamous lesions whereas absent / focal weak expression is seen in normal / inflamed / atrophic cervical epithelium. p16 expression has also been seen in non HPV related tumors like High grade serous carcinoma & Atypical uterine smooth muscle tumors like Leiomyosarcomas. Testing of oropharynyngeal squamous cell carcinomas with p16 is also indicated where it serves as an excellent surrogate marker for active HPV.
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