RENIN, DIRECT

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What is this Test About?
Renin is a proteolytic enzyme released from juxtaglomerular cells of the kidney. The enzyme cleaves a substrate to produce Angiotensin I which in turn produces Angiotensin II. This metabolite plays a key role in various forms of hypertension. Increased levels are seen in Renal hypertension, Addison?s disease and Secondary hypoaldosteronism. Low levels are detected in Hyporeninemic hypoaldosteronism and Primary aldosteronism.
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